| 货号 | FAB34761T-100UG |
| 别名 | interstitial; Plasma retinol-binding protein; RBP4; retinol binding protein 4, plasma; RetinolBinding Protein 4; retinol-binding protein 4, plasma |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse RBP4/Retinol‑Binding Protein 4 in direct ELISA and Western Blot. In Western blots, detects human RBP4/Retinol‑Binding Protein 4. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5950 (Human); 19662 (Mouse); 25703 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse RBP4/Retinol‑Binding Protein 4 Met1-Leu201 Accession # NP_035385 |
| 生物活性 | Human, Mouse |
| 标记 | Alexa Fluor 594 |
| 背景 | Retinol (also known as vitamin A) is unstable and insoluble in the aqueous solution. However, retinol becomes quite stable and soluble in plasma due to its tight interaction with Retinol-binding Protein 4 (RBP4), also known as Plasma Retinol-binding Protein (1‑3). A prototypic member of the lipocalin superfamily, RBP4 has a beta ‑barrel structure with a well-defined cavity. It is secreted from the liver, a process requiring the availability of retinol. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. The retinol-RBP4-TTR complex prevents the loss of RBP4 by filtration through the kidney and increases the stability of the retinol-RBP4 complex. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision. Serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes, implying that RBP4, an adipocyte-derived signal, may be a biomarker and a drug target for the two diseases. The amino acid sequence of mouse RBP4 is 99%, 86%, 83% and 75% identical to that of rat, human/chimpanzee, dog and chicken. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|