| 货号 | FAB5610V-100UG |
| 别名 | C19orf75; CD169; Siglec1; Siglec-1; SIGLECL1 SIGLEC family like 1 | 全称 | Sialic Acid Binding Ig-like Lectin 1 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects mouse Siglec-1/CD169 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human Siglec-1, -5, -6, -7, -8, -9, -10, -11, -14, recombinant mouse Siglec-2, -3, -E, -F, -G, or -H is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6614 (Human); 20612 (Mouse); 311426 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse Siglec-1/CD169 Thr20-Leu1639 (predicted) Accession # Q62230 |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 405 |
| 背景 | Siglec-1, also known as sialoadhesin or CD169, is a 175‑185 kDa type I transmembrane glycoprotein belonging to the Siglec family of sialic acid specific I-type lectins within the immunoglobulin superfamily. Mouse Siglec-1 contains a 1619 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and 16 Ig-like C2-set domains. The ECD shares 73% and 83% aa sequence identity with human and rat Siglec-1, respectively. Alternate splicing generates two soluble isoforms containing either 16 or the first 3 Ig-like domains. Siglec-1 is expressed by some tissue macrophages, dendritic cells and circulating monocytes during certain infections. It binds sialylated molecules including MMR, MGL1/CD301a, MUC1, PSGL-1 and CD43. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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