Mouse DPPIV/CD26 Phycoerythrin MAb (Clone 155202) (100 TESTS)【科瑞奥博】

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Mouse DPPIV/CD26 Phycoerythrin MAb (Clone 155202) (100 TESTS)

货号： FAB9541P 基本售价： 3529.5 元规格： 100 Tests

产品信息

概述
货号	FAB9541P
别名	ADABP; ADCP-2; ADCP2DPP IV; Adenosine deaminase complexing protein 2TP103; CD26 antigen; CD26; CD26T-cell activation antigen CD26; dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidyl-peptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP4; DPPIV; EC 3.4.14.5
全称	Dipeptidyl-peptidase IV
反应种属	Mouse
应用	Flow Cytometry
目标/特异性	Detects mouse DPPIV/CD26 in direct ELISAs.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1803 (Human); 13482 (Mouse); 102133935 (Cynomolgus Monkey)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse DPPIV/CD26 Extracellular domain
生物活性	Mouse
标记	Phycoerythrin
背景	DPPIV/CD26 (EC 3.4.14.5) is a serine exopeptidase that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides (1, 2). It is a type II membrane protein consisting of a short cytoplasmic tail, a transmembrane domain, and a long extracellular domain (3‑5). The extracellular domain contains glycosylation sites, a cysteine-rich region and the catalytic active site (Ser, Asp and His charge relay system). The amino acid sequence of the mouse DPPIV/CD26 extracellular domain is 84% and 91% identical to the human and rat counterparts, respectively. In the native state, DPPIV/CD26 is present as both a monomer and a noncovalently linked homodimer on the cell surface, the latter configuration being necessary for optimal activity. A soluble form is also detectable in human serum and other body fluids, the levels of which may have clinical significance in patients with cancer, liver and kidney disease, and depression. DPPIV/CD26 plays an important role in many biological and pathological processes. It functions as T cell-activating molecule (THAM). It serves as a co‑factor for entry of HIV in CD4⁺ cells (6). It binds adenosine deaminase, the deficiency of which causes severe combined immunodeficiency disease in humans (7). It cleaves chemokines such as stromal-cell-derived factor 1 alpha and macrophage-derived chemokine (8, 9). It degrades peptide hormones such as glucagon (10). It truncates procalcitonin, a marker for systemic bacterial infections with elevated levels detected in patients with thermal injury, sepsis and severe infection, and in children with bacterial meningitis (11).
运输条件	Blue Ice
存放说明	4℃
参考文献	Misumi, Y. and Y. Ikehara (2004) in Handbook of Proteolytic Enzymes. Barrett, A.J. et al. (eds), p. 1905, Elsevier, London. Ikehara, Y. et al. (1994) Methods Enzymol. 244:215. Marguet, D. et al. (1992) J. Biol. Chem. 267:2200. Bernard, A.M. et al. (1994) Biochemistry 33:15204. Vivier, I. et al. (1991) J. Immunol. 147:447. Callebaut, C. et al. (1993) Science 262:2045. Kameoka, J. et al. (1993) Science 261:466. Ohtsuki, T. et al. (1998) FEBS Lett. 431:236. Proost, P. et al. (1999) J. Biol. Chem. 274:3988. Hinke, S.A. et al. (2000) J. Biol. Chem. 275:3827. Wrenger, S. et al. (2000) FEBS Lett. 466:155.

参考图片

Detection of DPPIV/CD26 in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with Rat Anti-Mouse DPPIV/CD26 PE‑conjugated Monoclonal Antibody (Catalog # FAB9541P, filled histogram) or isotype control antibody (Catalog # IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.