Mouse CD8 alpha Alexa Fluor 594 MAb (Clone 53-6.7) (100 TESTS)
货号：
FAB116T-100 基本售价：
3390.7 元 规格：
100 Tests
产品信息
概述| 货号 | FAB116T-100 |
| 别名 | CD8; CD8A |
| 反应种属 | Mouse |
| 应用 | Flow Cytometry(5 µL/106cells)
|
| 目标/特异性 | Detects both the alpha and alpha chains of mouse CD8 (1). |
| 使用方法 | Flow Cytometry: 5 µL/106cells
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| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 925 (Human); 12525 (Mouse); 24930 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse thymus or spleen |
| 生物活性 | Mouse |
| 标记 | Alexa Fluor 594 |
| 背景 | CD8, also known as Ly-2, is a heterodimeric glycoprotein consisting of an alpha and beta chain. It is expressed on cytolytic T cells and functions in conjunction with the T cell receptor in the recognition of MHC/peptide complexes. Mouse CD8 (containing an alpha /Ly-2 or alpha ′/Lyt-2 chain) is an antigen co-receptor on the T cell surface which interacts with MHC I molecules on antigen presenting cells (1). The CD8 alpha beta heterodimer is expressed on a subpopulation of mature T cells (2, 3), while CD8 alpha, without CD8 beta, has been detected on subsets of gamma δ TCR-bearing T cells (4), intestinal intrathymic lymphocytes (5, 6) and dendritic cells (7, 8). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Bierer, B.E. et al. (1989) Annu. Rev. Immunol. 7:579.
- Li, Y. et al. (2013) Front. Immunol. 4:206.
- Hayakawa, K. et al. (1994) Science 263:1131.
- MacDonald, H.R. et al. (1990) Eur. J. Immunol. 20:927.
- Rocha, B. et al. (1992) Immunol. Today 13:449.
- Wang, J. and J.R. Klein (1994) Science 265:1860.
- Vermec, D. et al. (1992) J. Exp. Med. 176:47.
- Suss, G. and K. Shortman (1996) J. Exp. Med. 183:1789.
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参考图片Detection of CD8 alpha in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE‑conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse CD8 alpha Alexa Fluor® 594‑conjugated Monoclonal Antibody (Catalog # FAB116T) or (B) Rat IgG 2A Alexa Fluor 594 Isotype Control (Catalog # IC006T). View our protocol for Staining Membrane-associated Proteins. |
