| 货号 | FAB6127V-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | CD44 antigen; CD44 molecule (Indian blood group); CD44; CD44R; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; LHR; MC56; MDU2; MDU2CD44 antigen (homing function and Indian blood group system); MDU3; MDU3CDW44; MIC4; MIC4MGC10468; MUTCH-I; Pgp1; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human and mouse CD44 in flow cytometry. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 960 (Human); 12505 (Mouse); 25406 (Rat); 100126860 (Porcine) |
| 免疫原 | Myeloid leukemia M1 cells induced with Dexamethasone |
| 生物活性 | Human, Mouse |
| 标记 | Alexa Fluor 405 |
| 背景 | CD44, also known asECMR-III, Hermes, Pgp1, Ly-24, GP90, or HUTCH, is a ubiquitously expressedprotein that is the major receptor for hyaluronic acid (HA). Mediates cell-celland cell-matrix interactions through its affinity for HA, and possibly also throughits affinity for other ligands such as osteopontin, collagens, and matrixmetalloproteinases (MMPs). Adhesion with HA plays an important role in cellmigration, tumor growth and progression. In cancer cells, may play an importantrole in invadopodia formation. Also involved in lymphocyte activation,recirculation and homing, and in hematopoiesis. Mouse CD44 has a 22 amino acid (aa) signalsequence, an extracellular domain (ECD) with a 100 aa hyaluronan-bindingdisulfide-stabilized link region and a 48-463 aa stem region, a 21 aatransmembrane domain, and a 72 aa cytoplasmic domain. CD44 exists as a largenumber of different isoforms due to alternative RNA splicing. Clone IM7.8.1 hasbeen reported to recognize all isoforms of CD44. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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