Mouse DC-SIGN/CD209 Phycoerythrin MAb (Clone 902404) (25 TESTS)【科瑞奥博】

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Mouse DC-SIGN/CD209 Phycoerythrin MAb (Clone 902404) (25 TESTS)

货号： FAB8345P-025 基本售价： 1972.9 元规格： 25 Tests

产品信息

概述
货号	FAB8345P-025
简介	Recombinant Monoclonal Antibody
别名	CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin; CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; CLEC4LC-type lectin domain family 4 member L; DC-SIGN1; DC-SIGN1C-type lectin domain family 4, member L; DC-SIGNMGC129965; Dendritic cell-specific ICAM-3-grabbing non-integrin 1
全称	Dendritic Cell-specific ICAM-3-grabbing Non-integrin 1
反应种属	Mouse
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects mouse DC‑SIGN/CD209 in direct ELISAs.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	30835 (Human); 170786 (Mouse)
纯化方式	Protein A or G purified from cell culture supernatant
免疫原	NS0 mouse myeloma cell line transfected with mouse DC‑SIGN/CD209 Met1-Lys238 Accession # Q91ZX1
生物活性	Mouse
标记	Phycoerythrin
背景	Mouse Dendritic Cell-specific ICAM-3 Grabbing Non-integrin (DC-SIGN)/CD209, also known as CD209 Antigen-like Protein A, is a member of the C-type lectin family (1). Mouse DC-SIGN/CD209 is a 33 kDa, 238 amino acid (aa) type II transmembrane protein (2). The extracellular region contains a Ca²⁺-dependent carbohydrate-binding lectin domain (2). In addition to the full-length mouse DC-SIGN/CD209, a second, truncated splice variant has been reported. DC-SIGN/CD209 is not well conserved between mouse and human with the extracellular domain sharing only 63% aa identity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2-4). DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation (2, 5, 6).
运输条件	Blue Ice
存放说明	4℃
参考文献	Liu, W. et al. (2004) J. Biol. Chem. 279:18748. Caminschi, I. et al. (2001) Mol. Immunol. 38:365. Curtis, B.M. et al. (1992) Proc. Natl. Acad. Sci. USA 89:8356. Anthony, R.M. et al. (2008) Proc. Natl. Acad. Sci. USA 105:19571. Geijtenbeek, T.B. et al. (2000) Cell 100:575. Garcia-Vallejo, J.J. and Y. van Kooyk (2013) Trends Immunol. 34:482.

参考图片

Detection of DC‑SIGN/CD209 in Mouse Bone Marrow-derived Dendritic Cells by Flow Cytometry. Mouse bone marrow-derived dendritic cells were stained with Rat Anti-Mouse DC‑SIGN/CD209 PE‑conjugated Monoclonal Antibody (Catalog # FAB8345P, filled histogram) or isotype control antibody (Catalog # IC013P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of DC‑SIGN/CD209 in CHO Chinese Hamster Cell Line Transfected with Mouse DC-SIGN/CD209 by Flow Cytometry. CHO Chinese hamster ovary cell line transfected with mouse DC-SIGN/CD209 was stained with Rat Anti-Mouse DC‑SIGN/CD209 PE‑conjugated Monoclonal Antibody (Catalog # FAB8345P, filled histogram) or isotype control antibody (Catalog # IC013P, open histogram). View our protocol for Staining Membrane-associated Proteins.