Human/Mouse/Rat CCR5 Allophycocyanin MAb (Clone CTC5) (25 TESTS)【科瑞奥博】

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Human/Mouse/Rat CCR5 Allophycocyanin MAb (Clone CTC5) (25 TESTS)

货号： FAB1802A-025 基本售价： 1685.4 元规格： 25 Tests

产品信息

概述
货号	FAB1802A-025
别名	C-C CKR-5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5FLJ78003; CCR5; CCR-5; CD195 antigen; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; HIV-1 fusion coreceptor; IDDM22CMKBR5C-C chemokine receptor type 5
反应种属	Human/Mouse/Rat
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human CCR5 in Western blots. For additional information regarding epitope specificity for this antibody and other R&D Systems anti‑human CCR5 antibodies, see Reference 1.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1234 (Human); 12774 (Mouse); 117029 (Rat); 484789 (Canine); 493769 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. CCR5 antagonist blocks metastasis of basal breast cancer cells. Authors: Velasco-Velazquez M, Jiao X, De la Fuente M, Pestell T, Ertel A, Lisanti M, Pestell R Cancer Res, 2102;72(15):3839-50. Species: Human Sample Type: Whole Cells Application: Flow CIB1 and CIB2 are HIV-1 helper factors involved in viral entry Sci Rep, 2016;6(0):30927. Species: Human Sample Type: Whole Cells Application: Flow CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines. Authors: Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Ando S, Fatatis A, Paudyal B, Cristofanilli M, Thakur M, Lisanti M, Pestell R Cancer Res, 2015;74(23):7103-14. Species: Human Sample Type: Whole Cells Application: Flow HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells. Authors: Prendergast A, Prado JG, Kang YH, Chen F, Riddell LA, Luzzi G, Goulder P, Klenerman P AIDS, 2010;24(4):491-502. Species: Human Sample Type: Whole Cells Application: Flow Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. Authors: Bayry J, Triebel F, Kaveri SV, Tough DF J. Immunol., 2007;178(7):4184-93. Species: Human Sample Type: Whole Cells Application: ICC
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	CHO Chinese hamster ovary cell line transfected with human CCR5
生物活性	Human, Mouse, Rat
标记	APC
背景	CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a coreceptor for Macrophage Tropic HIV-1 infection.
运输条件	Blue Ice
存放说明	4℃
参考文献	Lee, B. et al. (1999) J. Biol. Chem. 274:9617.

参考图片

Detection of CCR5 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD3 epsilon Alexa Fluor® 405‑conjugated Monoclonal Antibody (Catalog # FAB100V) and either (A) Mouse Anti-Human/Mouse/Rat CCR5 APC‑conjugated Monoclonal Antibody (Catalog # FAB1802A) or (B) Mouse IgG₁ Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.

Detection of CCR5 in Mouse Splenocytes by Flow Cytometry.

Mouse splenocytes treated with anti-CD3, anti-CD28, 5 ng/mL Recombinant Mouse IL‑12 (Catalog # 419‑ML) and 10 μg/mL Goat Anti-Mouse IL‑4 Polyclonal Antibody (Catalog # AB-404-NA) to induce Th1 development for 3 days were stained with Mouse Anti-Human/Mouse/Rat CCR5 APC‑conjugated Monoclonal Antibody (Catalog # FAB1802A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of CCR5 in Rat Splenocytes by Flow Cytometry. Rat splenocytes were stained with Mouse Anti-Human/Mouse/Rat CCR5 APC‑conjugated Monoclonal Antibody (Catalog # FAB1802A) and Anti-Rat CD3 PE-conjugated Antibody. Quadrant markers were set based on control antibody staining (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.