Human/Rat CCR4 Fluorescein MAb (Clone 205410) (25 TESTS)【科瑞奥博】

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Human/Rat CCR4 Fluorescein MAb (Clone 205410) (25 TESTS)

货号： FAB1567F-025 基本售价： 1685.4 元规格： 25 Tests

产品信息

概述
货号	FAB1567F-025
简介	Clone 205410 was used by HLDA to establish CD designation
别名	C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4HGCN:14099; CCR-4; CD194 antigen; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; ChemR13; CKR4MGC88293; CMKBR4k5-5; K5-5
反应种属	Human/Rat
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1233 (Human); 12773 (Mouse); 171054 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. Authors: James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, Gersuk V, OBrien K, Nguyen Q, Zeitner B, Lanteri M, Norris P, Chaussabel D, Malhotra U, Kwok W PLoS Pathog, 2016;12(1):e1005375. Species: Human Sample Type: Whole Cells Application: Flow Identification of human NK17/NK1 cells. Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA PLoS ONE, 2011;6(10):e26780. Species: Human Sample Type: Whole Cells Application: Flow Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH J. Immunol., 2010;184(6):2886-98. Species: Human Sample Type: Whole Cells Application: Flow Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission. Authors: Finney OC, Nwakanma D, Conway DJ, Walther M, Riley EM Eur. J. Immunol., 2009;39(5):1288-300. Species: Human Sample Type: Whole Cells Application: Flow Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E J. Immunol., 2009;183(9):5494-501. Species: Human Sample Type: Whole Cells Application: Flow CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. Authors: Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A J. Immunol., 2007;179(3):1996-2004. Species: Human Sample Type: Whole Cells Application: Flow Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Authors: Garcia G, Humbert M, Capel F, Rimaniol AC, Escourrou P, Emilie D, Godot V Allergy, 2007;62(2):170-7. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Human CCR4 transfectants Met1-Leu360 Accession # P51679
生物活性	Human, Rat
标记	Fluorescein
背景	CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Human CD Marker Products Regulatory T Cells (Tregs) T Cell Migration/Adhesion Th17 Cells Th2 Cells Th22 Cells

参考图片

Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human/Rat CCR4 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1567F) and Mouse Anti-Human CD3 epsilon APC‑conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining (Catalog # IC0041F). View our protocol for Staining Membrane-associated Proteins.