Human/Mouse CD44 Alexa Fluor 647 MAb (Clone IM7.8.1R) (25 TESTS)
货号：
FAB6127R-025 基本售价：
1546.6 元 规格：
25 Tests
产品信息
概述| 货号 | FAB6127R-025 |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | CD44 antigen; CD44 molecule (Indian blood group); CD44; CD44R; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; LHR; MC56; MDU2; MDU2CD44 antigen (homing function and Indian blood group system); MDU3; MDU3CDW44; MIC4; MIC4MGC10468; MUTCH-I; Pgp1; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I |
| 反应种属 | Human/Mouse |
| 应用 | Flow Cytometry(5 µL/106cells)
|
| 目标/特异性 | Detects human and mouse CD44 in flow cytometry. |
| 使用方法 | Flow Cytometry: 5 µL/106cells
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 960 (Human); 12505 (Mouse); 25406 (Rat); 100126860 (Porcine) |
| 纯化方式 | Protein A or G purified from cell culture supernatant |
| 免疫原 | Myeloid leukemia M1 cells induced with Dexamethasone |
| 生物活性 | Human, Mouse |
| 标记 | Alexa Fluor 647 |
| 背景 | CD44, also known asECMR-III, Hermes Antigen, Pgp1, Ly-24, GP90, and HUTCH-I, is a ubiquitously expressedprotein that is the major receptor for hyaluronic acid (HA). CD44 mediates cell-celland cell-matrix interaction through its affinity for HA, and possibly also throughits affinity for other ligands such as osteopontin, collagen, and matrixmetalloproteinases (MMPs). Adhesion with HA plays an important role in cellmigration, tumor growth and progression. In cancer cells, may play an importantrole in invadopodia formation. Also involved in lymphocyte activation,recirculation and homing, and in hematopoiesis. Mouse CD44 has a 22 amino acid (aa) signalsequence, an extracellular domain (ECD) with a 100 aa hyaluronan-bindingdisulfide-stabilized link region and a 48-463 aa stem region, a 21 aatransmembrane domain, and a 72 aa cytoplasmic domain. CD44 exists as a largenumber of different isoforms due to alternative RNA splicing. Clone IM7.8.1 hasbeen reported to recognize all isoforms of CD44. In the ECD, human and mouse CD44 share about 65% aa sequence identity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Adipose-derived Stem Cell Markers
- B Cell Markers
- Basophils
- Cancer Biomarkers
- Cancer Stem Cell Markers
- Chondrogenesis Markers
- Dendritic Cell Adhesion and Migration
- Glial Lineage Markers
- Granulocyte Markers
- Hematopoietic Stem Cell Markers
- Human CD Marker Products
- Hyaluronan (HA) and HA-binding Proteins
- ICC / IHC Images: CD44
- Leukocyte Receptors/Markers in Allergy and Asthma
- Lymphoma
- Mesenchymal Stem Cell Markers
- Mini-review: CD44
- Multiple Myeloma
- Myeloid Lineage Markers
- Myeloid-derived Suppressor Cells (MDSC)
- Natural Killer T (NKT) Cells
- NCR+ILC3
- Need help at the cell surface? Ask your local sheddase.
- Osteoblast and Osteoclast Markers
- Regulatory T Cells (Tregs)
|
参考图片Detection of CD44 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cell (PBMCs) were stained with Rat Anti-Human/Mouse CD44 Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB6127R, filled histogram) or isotype control antibody (Catalog # IC013R, open histogram). View our protocol for Staining Membrane-associated Proteins. |
Detection of CD44 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Human/Mouse CD44 Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB6127R, filled histogram) or isotype control antibody (Catalog # IC013R, open histogram). View our protocol for Staining Membrane-associated Proteins. |
