Mouse NCAM-1/CD56 Alexa Fluor 488 MAb (Clone 809220) (25 TESTS)【科瑞奥博】

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Mouse NCAM-1/CD56 Alexa Fluor 488 MAb (Clone 809220) (25 TESTS)

货号： FAB7820G-025 基本售价： 1407.8 元规格： 25 Tests

产品信息

概述
货号	FAB7820G-025
别名	CD56 / NCAM-1; CD56 antigen; CD56; MSK39; N-CAM-1; NCAM-1; NCAMantigen recognized by monoclonal 5.1H11; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM
全称	Neural Cell Adhesion Molecule
反应种属	Mouse
应用	Flow Cytometry(5 µL/10⁶cells)
目标/特异性	Detects mouse NCAM‑1/CD56 in direct ELISAs.
使用方法	Flow Cytometry: 5 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	4684 (Human); 17967 (Mouse); 24586 (Rat)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse NCAM‑1/CD56 Leu20-Thr711 Accession # P13595
生物活性	Mouse
标记	Alexa Fluor 488
背景	NCAM-1 (Neural adhesion molecule-1; also CD56) is a 120-190 kDa glycoprotein member of the Ig Superfamily. It is expressed on multiple cell types, both in the embryo and adult. Here, it serves as both an adhesion molecule and a receptor for multiple ligands, including as FGFR, PDGF, GDNF and agrin. On the cell surface, it is a cis-oriented homodimer that can form homodimers in-trans with other cis-homodimers. In the embryo, NCAM-1 is polysialylated (PolySia), and shows a MW of 200-220 kDa in SDS-PAGE. This polysialylation reduces the ability of NCAM-1 to dimerize. Mature mouse NCAM-1 is a 1096 amino acid (aa) type I transmembrane (TM) protein (aa 20-1115). It possesses a 692 aa extracellular region (aa 20-711) and a 386 aa cytoplasmic domain. The extracellular region contains five consecutive C2-type Ig-like domains (aa 20-492) followed by two FN type-III domains (aa 497-692). Multiple splice variants exist. There is a 140 kDa TM variant that shows a deletion of aa 810-1076, and a 120 kDa variant that is GPI-linked and shows a 24 aa substitution for aa 702-1115. A third potential variant contains a five aa substitution for aa 601-1115. Over aa 20-711, mouse NCAM-1 shares 99% and 95% aa identity with rat and human NCAM-1, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	Acute Myeloid Leukemia Adult Neurogenesis Cancer Biomarkers Conventional/Classical Dendritic Cells GDNF Family Group 1 ILCs Human CD Marker Products ICC / IHC Images: NCAM-1/CD56 Immunoglobulin Superfamily CAMs Inflammatory/Monocyte-derived Dendritic Cells Isolation, Culture, and Identification of Natural Killer Cells Langerhans and Dermal Dendritic Cells Lymphoid Lineage Markers Mesenchymal Stem Cell Markers Multiple Myeloma Myogenesis Markers Myogenic Precursor Markers Natural Killer T (NKT) Cells NCAM as a Novel GDNF Family Receptor NCR+ILC3 NCR-ILC3 Neural Progenitor Cell Markers Plasmacytoid Dendritic Cells Skeletal Muscle Markers Synaptic Adhesion Molecules Synaptic Proteins

参考图片

Detection of NCAM‑1/CD56 in Neuro‑2A Mouse Cell Line by Flow Cytometry. Neuro‑2A mouse neuroblastoma cell line was stained with Rat Anti-Mouse NCAM‑1/CD56 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB7820G, filled histogram) or isotype control antibody (Catalog # IC006G, open histogram). View our protocol for Staining Membrane-associated Proteins.