Mouse CD8 alpha Fluorescein MAb (Clone 53-6.7) (25 TESTS)【科瑞奥博】

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Mouse CD8 alpha Fluorescein MAb (Clone 53-6.7) (25 TESTS)

货号： FAB116F-025 基本售价： 981.5 元规格： 25 Tests

产品信息

概述
货号	FAB116F-025
别名	CD8; CD8A
反应种属	Mouse
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects both the alpha and alpha chains of mouse CD8 (1).
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	925 (Human); 12525 (Mouse); 24930 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis. Authors: Freitas E, Nico D, Alves-Silva M, Morrot A, Clinch K, Evans G, Tyler P, Schramm V, Palatnik-de-Sousa C PLoS Negl Trop Dis, 2015;9(12):e0004297. Species: Mouse Sample Type: Whole Cells Application: Flow Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G Int. Immunol., 2009;21(5):555-65. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse thymus or spleen
生物活性	Mouse
标记	Fluorescein
背景	CD8, also known as Ly-2, is a heterodimeric glycoprotein consisting of an alpha and beta chain. It is expressed on cytolytic T cells and functions in conjunction with the T cell receptor in the recognition of MHC/peptide complexes. Mouse CD8 (containing an alpha /Ly-2 or alpha ′/Lyt-2 chain) is an antigen co‑receptor on the T cell surface which interacts with MHC I molecules on antigen presenting cells (1). CD8 alpha beta heterodimer is expressed on a subpopulation of mature T cells (2, 3). CD8 alpha, without CD8 beta, has been detected on subsets of gamma δ TCR-bearing T cells (4), intestinal intrathymic lymphocytes (5, 6) and dendritic cells (7, 8).
运输条件	Blue Ice
存放说明	4℃
参考文献	Bierer, B.E. et al. (1989) Annu. Rev. Immunol. 7:579. Ledbetter, J.A. et al. (1980) J. Exp. Med. 152:280. Hayakawa, K. et al. (1994) Science 263:1131. MacDonald, H.R. et al. (1990) Eur. J. Immunol. 20:927. Rocha, B. et al. (1992) Immunol. Today 13:449. Wang, J. and J.R. Klein (1994) Science 265:1860. Vermec, D. et al. (1992) J. Exp. Med. 176:47. Suss, G. and K. Shortman (1996) J. Exp. Med. 183:1789.

参考图片

Detection of CD8 alpha in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CD8 alpha Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB116F, filled histogram) or isotype control antibody (Catalog # IC006F, open histogram). View our protocol for Staining Membrane-associated Proteins.