CD282 pure, functional grade, mouse+ hum
货号：
130-098-855 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-098-855 |
| 描述 | Clone REA109 recognises human and mouse CD282, also known as toll-like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type 1 transmembrane proteins with extracellular leucine-rich repeats and intracellular toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram+and Gram– bacteria, lipoteichoic acid (LTA) in Gram+ bacteria, lipoarabinomannan and lipomannan from Mycoplasma, and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and triacylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial, and epithelial cells. Additional information: Clone REA109 displays negligible binding to Fc receptors. |
| 别名 | TLR2, TIL4, Ly105 |
| 克隆号 | REA109 |
| 同种亚型 | recombinant human IgG1 |
