CD18 pure, mouse functional grade
货号：
130-106-229 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-106-229 |
| 描述 | Clone M18/2 recognizes the CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation. |
| 别名 | Integrin beta-2 (ITGB2), LTbetaR, Ltar, TNF-R-III, LTBR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, TNFCR |
| 克隆号 | M18/2 |
| 同种亚型 | rat IgG2aκ |
