CD27 (REA499)-FITC, h, m 30 tests
货号：
130-108-251 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-108-251 |
| 描述 | Clone REA499 recognizes the human and mouse CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)-induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on NK, T, and B cell populations. In human and mice, the majority of CD4+ and CD8+ naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27+ B cells display all the functional and phenotypic characteristics of memory cells.Additional information: Clone REA499 displays negligible binding to Fc receptors. |
| 别名 | S152, TNFRSF7, Tp55, T14 |
| 克隆号 | REA499 |
| 同种亚型 | recombinant human IgG1 |
