Anti-H2AX pS139-FITC, h, m 30 tests
货号：
130-107-628 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-107-628 |
| 描述 | Clone REA502 recognizes the human and mouse Histone H2AX antigen phosphorylated at serine 139 (pS139). H2AX is a 14 kD basal histone and a variant of the H2 histone family. It replaces conventional H2A in a subset of nucleosomes. When cells are exposed to ionizing radiation or DNA-damaging chemotherapeutic agents, double-stranded breaks (DSBs) are generated that rapidly result in the phosphorylation of H2AX at serine 139 (γH2AX). Because phosphorylation of H2AX is abundant, fast, and correlates well with each DSB, it is the most sensitive marker that can be used to examine the DNA damage produced and the subsequent repair of the DNA lesion. γH2AX also participates in the evolutionarily conserved process of sister chromatid recombination, a homologous recombination pathway involved in the suppression of genomic instability during DNA replication and directly implicated in tumor suppression.Additional information: Clone REA502 displays negligible binding to Fc receptors. |
| 别名 | H2AFX, H2AX, H2a/x, H2A.X, γ-H2AX, γH2AX |
| 克隆号 | REA502 |
| 同种亚型 | recombinant human IgG1 |
