Anti-TIGIT-APC, mouse
货号：
130-108-261 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-108-261 |
| 描述 | Clone REA536 recognizes the mouse T cell immunoreceptor with Ig and ITIM domains (TIGIT) antigen, a single-pass type I membrane protein, which is also known as V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT belongs to a PVR family of type 1 proteins that also binds to CD155 and CD112 ligands . It is expressed on peripheral memory and regulatory CD4+ T cells and NK cells and is upregulated following activation on naive CD4+ T cells. Its interaction with CD155 induces tolerogenic dendritic cells that impaire T cell proliferation and inhibit IFN-γ production from responding T cells. Like the well-characterized CD28/CTLA-4 costimulatory pathway, a newly emerging pathway consisting of CD226 and TIGIT has been associated with susceptibility to multiple autoimmune diseases.Additional information: Clone REA536 displays negligible binding to Fc receptors. |
| 别名 | Vstm3, WUCAM |
| 克隆号 | REA536 |
| 同种亚型 | recombinant human IgG1 |
