CD64 (FcgRI)-APC, mouse 60 tests
货号：
130-103-879 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-103-879 |
| 描述 | Clone REA286 recognizes the CD64 antigen, a 72 kDa integral membrane glycoprotein also known as high affinity immunoglobulin gamma Fc receptor I (FcγRI). Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively expressed on macrophages, monocytes, dendritic cells, and mast cells. Treatment with cytokines like IFN-γ and G-CSF induces CD64 upregulation. CD64 binds monomeric IgG-type antibodies with high affinity and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release, and superoxide generation.Additional information: Clone REA286 displays negligible binding to Fc receptors. |
| 别名 | FCGR1, FcgammaRI, IGGHAFC, FcR I, FcγRI |
| 克隆号 | REA286 |
| 同种亚型 | recombinant human IgG1 |
