Anti-LPAM-1-APC, mouse 60 tests
货号：
130-107-012 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-107-012 |
| 描述 | Clone REA457 recognizes the mouse Peyer’s patch adhesion molecule 1 (LPAM-1) antigen, a heterodimeric glycoprotein receptor, which is also known as α4β7 integrin. LPAM-1 is a cell surface adhesion molecule involved in lymphocyte trafficking and lymphocyte-cell and matrix interactions. It is expressed on T and B cells. Lymphocytes in spleen and mesenteric lymph nodes have low levels of LPAM-1 expression but can up-regulate their LPAM-1 expression on activation. Cellular ligands include vascular cell adhesion molecule 1 (VCAM-1) and the mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is present on high endothelial venules of mucosal lymphoid organs. Interaction of LPAM-1 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut. Additional information: Clone REA457 displays negligible binding to Fc receptors. |
| 别名 | ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, M290 IEL, CD49d |
| 克隆号 | REA457 |
| 同种亚型 | recombinant human IgG1 |
