CD20-PE, mouse 60 tests
货号：
130-105-007 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-105-007 |
| 描述 | Clone REA294 recognizes the murine CD20 antigen, a 32kDa membrane protein also known as B-cell differentiation antigen Ly-44. CD20 is a B lymphocyte-specific cell-surface molecule involved in the regulation of transmembrane Ca2+ conductance and cell-cycle progression during human B cell activation. CD20 is first expressed by human pre-B cells in the bone marrow, predominantly after Ig heavy chain rearrangement, with expression persisting until plasma cell differentiation. Antibody binding to CD20 inhibits B cell progression within the cell cycle following mitogen stimulation, and inhibits mitogen-induced B cell differentiation and antibody secretion. Extensive CD20 crosslinking can also influence apoptosis. The majority of human B cell-lineage malignancies express CD20. Because of this, in humans anti-CD20 monoclonal antibodies have become an effective therapy for non-Hodgkins lymphoma.Additional information: Clone REA294 displays negligible binding to Fc receptors. |
| 别名 | MS4A1, Ly-44, MS4A2 |
| 克隆号 | REA294 |
| 同种亚型 | recombinant human IgG1 |
