Anti-IL-27 p28-PE, mouse 60 tests
货号：
130-105-702 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-105-702 |
| 描述 | Clone REA371 recognizes the mouse IL-27 p28 antigen, a secreted molecule which binds Epstein-Barr virus-induced gene 3 (EBI3) to form the heterodimeric cytokine IL-27. IL-27 is expressed by antigen-presenting cells, including macrophages and dendritic cells, in the early phase after antigen-mediated activation. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells. In vivo, its most important role appears to be that of immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses in a range of infectious and noninfectious situations. These activities of IL-27 are dependent on simultaneous T cell receptor activation and occur in synergy with IL-12. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL-27 p28 is only poorly secreted without coexpression of EBI3.Additional information: Clone REA371 displays negligible binding to Fc receptors. |
| 别名 | Il30, p28, IL-27A |
| 克隆号 | REA371 |
| 同种亚型 | recombinant human IgG1 |
