Anti-Bcl-2-PE, mouse 60 tests
货号：
130-105-473 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-105-473 |
| 描述 | Clone REA356 recognizes the mouse Bcl-2 antigen, a 26 kDa intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is the founding member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Additional information: Clone REA356 displays negligible binding to Fc receptors. |
| 别名 | BCL2, Apoptosis regulator Bcl-2 |
| 克隆号 | REA356 |
| 同种亚型 | recombinant human IgG1 |
