Anti-c-Rel-PE, mouse 60 tests
货号：
130-106-187 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-106-187 |
| 描述 | Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-κB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as Il-2 and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity.Additional information: Clone REA397 displays negligible binding to Fc receptors. |
| 别名 | REL |
| 克隆号 | REA397 |
| 同种亚型 | recombinant human IgG1 |
