Anti-DCAR1-Biotin, mouse 200 tests
货号：
130-101-887 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-101-887 |
| 描述 | Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a+ DC subsets in spleen and thymus and on subsets of CD11b+ myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses in vivo. Triggering DCAR1 via monoclonal antibody ligation on CD8+ DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice. |
| 别名 | CLEC4B1, Aplra2, Clec4b, DCAR, DCARbeta, Dcar2 |
| 克隆号 | SKa5-3D5 |
| 同种亚型 | rat IgG2b |
