CD123-Biotin, mouse 200 tests
货号：
130-101-932 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-101-932 |
| 描述 | Clone REA114 recognizes CD123, the alpha chain of the IL-3 receptor. CD123 is 60–70 kDa membrane glycoprotein and interacts in mice with common beta chain (betac) and beta IL-3 subunits to form functional heterodimeric IL-3 receptors. CD123 alone can bind IL-3 with low affinity, however a high affinity binding is displayed by the heterodimeric forms. Besides ligand binding, the alpha chain of IL-3R was also shown to be necessary for the activation of STAT-5. Expression of CD123 is widely found in hematopoietic cells and in addition on basophils, mast cells, and megakaryocytes. AKR, RF, A/J, and NZB mouse strains carry a 5-bp deletion in the IL-3Ra gene and thus lack the expression of CD123. Additional information: Clone REA114 displays negligible binding to Fc receptors. |
| 别名 | IL3RA, CDw123, SUT-1 |
| 克隆号 | REA114 |
| 同种亚型 | recombinant human IgG1 |
