CD101-Biotin, mouse 200 tests
货号：
130-104-302 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-104-302 |
| 描述 | Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as Immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8+ T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DC inhibits T cell proliferation via IL-10 production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4+CD25+ T regulatory cells both in vitro and in vivo.Additional information: Clone REA301 displays negligible binding to Fc receptors. |
| 别名 | EWI-101, Gm1016, Gm734, IGSF2 |
| 克隆号 | REA301 |
| 同种亚型 | recombinant human IgG1 |
