Anti-Tim-1-Biotin, mouse 200 tests
货号：
130-106-298 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-106-298 |
| 描述 | Clone RMT1-17 recognizes the mouse T-cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a Single-pass type I membrane protein also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Th1, Th2, Th17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naïve CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Th1/Th17 cytokine production. |
| 别名 | KIM-1, TIMD-1, HAVcr-1, TIM, TIM1 |
| 克隆号 | RMT1-17 |
| 同种亚型 | rat IgG1κ |
