Anti-Ly49a-Biotin, mouse 200 tests
货号：
130-101-892 基本售价：
询价 规格：
200 tests
产品信息
概述| 货号 | 130-101-892 |
| 描述 | Clone A1 recognizes Ly-49A, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells. |
| 别名 | KLRA1, A1, CH29-493D4.3, Klra22, Ly49v |
| 克隆号 | A1 |
| 同种亚型 | mouse IgG2aκ |
