Anti-ChemR23 (CMKLR1)-PE, mouse 60 tests
货号：
130-106-966 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-106-966 |
| 描述 | Clone REA461 recognizes the mouse G-protein coupled receptor ChemR23 antigen, a multi-pass membrane protein, which is also known as chemokine-like receptor 1 (CMKLR1). During dendritic cell (DC) differentiation from bone marrow, ChemR23 is upregulated early and then diminishes with time in culture. Most DC in vivo do not detectably express the receptor. In contrast, freshly isolated F4/80+/CD11b+ mouse peritoneal macrophages express ChemR23, display calcium signaling and migration to the active ligand. A small population of blood-borne F4/80+/CD11b+ macrophages also expresses ChemR23. Its natural ligand, chemerin, acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation and phosphorylation of ERK-1/ERK-2 MAP kinases. ChemR23 positively regulates adipogenesis and adipocyte metabolism.Additional information: Clone REA461 displays negligible binding to Fc receptors. |
| 别名 | Cmklr1, Dez, Gpcr27, mcmklr1 |
| 克隆号 | REA461 |
| 同种亚型 | recombinant human IgG1 |
