Anti-Ly-49e/f-FITC, mouse 60 tests
货号：
130-103-335 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-103-335 |
| 描述 | Clone REA218 recognizes the mouse killer cell lectin-like receptor 5 and 6 (Ly-49E and Ly-49F) antigens, which are type II transmembrane natural killer cell receptors belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. Ly-49E is expressed abundantly on fetal or immature NK cells and on certain γδ T cells, but at barely detectable frequencies on adult splenic NK cells. Different from other Ly-49 receptors, Ly-49E contains an immunoreceptor tyrosine-based inhibitory motif domain, a charged transmembrane residue and it is present in all mouse strains. Its failure to bind to a variety of soluble or cell bound MHC class I molecules indicates that its natural ligand is not an endogenous class I molecule. IL-2 and IL-15 selectively induce the de novo expression of Ly-49E on the majority of mature NK cells. By contrast, IL-4 blocks this IL-2 induced acquisition of Ly-49E. Ly-49F is expressed on subsets of NK cells, NK-T cells, and on a subpopulation of memory T cells in C57BL/6 mice, but not AKR/J, BALB/c, C3H/HeN, DBA/1, or SJL mice. IL-21 selectively down-regulates Ly-49F on mature NK cells.Additional information: Clone REA218 displays negligible binding to Fc receptors. |
| 别名 | KLRA5, Ly49e, Ly-49F, Klra6 |
| 克隆号 | REA218 |
| 同种亚型 | recombinant human IgG1 |
