CD47-Biotin, mouse 60 tests
货号：
130-102-056 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-102-056 |
| 描述 | Clone REA170 recognizes CD47, which is also known as integrin-associated protein. CD47 is a 50 KDa heavily glycosylated protein with an extracellular IgV domain, five transmembrane domains and a cytoplasmic tail, which exists in 4 different isoforms. The expression of CD47 varies in different tissue types depending upon the cytoplasmic tail isoform associated, for e.g the 16 amino acid form 2, is expressed in all cells of hematopoietic origin, endothelial and epithelial cells whereas 36 amino acids form 4 is expressed mainly in neurons, intestine, and testis. CD47 can interact with integrins, Thrombospondin-1 (TSP-1), cell surface gylcoproteins SIRPα and SIRPβ. Owing to these interactions, CD47 plays an important role in lymphocyte homeostasis, maturation and activation of dendritic cells, cellular transmigration and phagocytosis of cells. Additional Information: Clone REA170 displays negligible binding to Fc receptors. |
| 别名 | Integrin-associated Protein, IAP, Itgp, CD47 |
| 克隆号 | REA170 |
| 同种亚型 | recombinant human IgG1 |
