CD79b-Biotin, mouse 60 tests
货号：
130-105-891 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-105-891 |
| 描述 | Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice. |
| 别名 | B29, Igbeta, Igb |
| 克隆号 | HM79-12 |
| 同种亚型 | hamster IgG |
