CD62P-Biotin, mouse 60 tests
货号：
130-105-587 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-105-587 |
| 描述 | Clone REA344 recognizes the mouse CD62P antigen, a 140 kD Single-pass type I membrane protein also known as P-selectin or Platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, P-selectin is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of P-selectin with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells - an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, P-selectin also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells.Additional information: Clone REA344 displays negligible binding to Fc receptors. |
| 别名 | SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin |
| 克隆号 | REA344 |
| 同种亚型 | recombinant human IgG1 |
