CD6-Biotin, mouse 60 tests
货号：
130-104-664 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-104-664 |
| 描述 | Clone REA311 recognizes the murine CD6 antigen, a Single-pass type I membrane protein which is expressed on most CD4+CD8+ double-positive, CD4+ or CD8+ single-positive thymocytes, and at highest levels on mature CD3+ thymocytes. In marked contrast to human CD6, mouse CD6 has a long cytoplasmic tail that is not closely related to other proteins. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. In thymocytes that express heterogeneous TCR, CD6 increases occur as double-positive thymocytes are selected to a single-positive stage. In contrast, in thymocytes from TCR transgenic mice, CD6 is barely increased following selection, suggesting that as functional avidity increases, requirements for CD6-dependent co-stimulation decrease. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection.Additional information: Clone REA311 displays negligible binding to Fc receptors. |
| 别名 | T-cell differentiation antigen CD6 |
| 克隆号 | REA311 |
| 同种亚型 | recombinant human IgG1 |
