CD49a-Biotin, mouse, rat 60 tests
货号：
130-107-631 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-107-631 |
| 描述 | Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin α1 (Itga1). CD49a binds to CD29 (integrin β1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-γ production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation.Additional information: Clone REA493 displays negligible binding to Fc receptors. |
| 别名 | Itga1, VLA-1 |
| 克隆号 | REA493 |
| 同种亚型 | recombinant human IgG1 |
