CD275 (B7-H2)-Biotin, mouse 60 tests
货号：
130-102-030 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-102-030 |
| 描述 | Clone HK5.3 recognises murine CD275, which is also known as B7-H2 and ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of costimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 costimulates T cells upon binding to ICOS, which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell costimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells. |
| 别名 | ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, ICOSL, GL50 |
| 克隆号 | HK5.3 |
| 同种亚型 | rat IgG2aκ |
