CD209b (SIGN-R1)-Biotin, mouse 60 tests
货号：
130-106-402 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-106-402 |
| 描述 | Clone REA125 recognizes the mouse CD209b antigen, a Single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on DCs but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens in vivo through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria in vitro.Additional information: Clone REA125 displays negligible binding to Fc receptors. |
| 别名 | DC-SIGNR1, OtB7, SIGNR1, mSIGNR1 |
| 克隆号 | REA125 |
| 同种亚型 | recombinant human IgG1 |
