CD185(CXCR5)-Biotin, mouse 60 tests
货号：
130-102-057 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-102-057 |
| 描述 | Clone REA215 recognizes murine CD185, which is a 42 kDa multipass chemokine receptor, also known as CXCR5 or BLR (burkitt lymphoma receptor-1). Expression of CD185 is found on mature recirculating B cells, a small subset of CD4+ and CD8+ T cells, and skin-derived migratory dendritic cells. CXCR5 recognizes B cell–attracting chemokine 1 (BCA-1)/ CXCL13 as ligand, which is a homeostatic chemokine, constitutively secreted by stromal cells in B cell areas of secondary lymphoid tissues (follicles). CXCR5 is involved in recruitment of circulating naive B cells to follicles and trafficking and homing of B1 B cells. Mice lacking CXCR5 gene display defective primary follicles and germinal centers formation in the spleen and Peyer patches, and lack inguinal lymph nodes. Additional information: Clone REA215 displays negligible binding to Fc receptors. |
| 别名 | CXCR5, BLR1, CXC-R5, CXCR-5, Gpcr6, MDR15 |
| 克隆号 | REA215 |
| 同种亚型 | recombinant human IgG1 |
