CD120b (TNF-R II)-Biotin, mouse 60 tests
货号：
130-104-743 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-104-743 |
| 描述 | Clone REA228 recognizes the extracellular part of the membrane-bound and truncated soluble form of the mouse CD120b antigen, a 75 kD type I transmembrane protein, which is also known as Tumor Necrosis Factor Receptor Type II (TNF-RII). CD120b is a receptor with high affinity for the mouse cytokine TNF-α and with lower affinity for LT-α. It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA228 displays negligible binding to Fc receptors. |
| 别名 | TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor |
| 克隆号 | REA228 |
| 同种亚型 | recombinant human IgG1 |
