CD106 (VCAM-1)-Biotin, mouse 60 tests
货号：
130-104-758 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-104-758 |
| 描述 | Clone 429 (MVCAM.A) recognizes the mouse CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. |
| 别名 | VCAM1, INCAM-100 |
| 克隆号 | 429 (MVCAM.A) |
| 同种亚型 | rat IgG2aκ |
