Anti-B7-H4-Biotin, mouse 60 tests
货号：
130-106-411 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-106-411 |
| 描述 | Clone REA392 recognizes the mouse B7-H4 antigen, a glycosylphosphatidylinositol (GPI) linked protein which is also known as V-set domain containing T-cell activation inhibitor 1 (Vtcn1). The B7 family of T cell costimulatory and coinhibitory molecules plays a pivotal role in the regulation of adaptive immune responses. As such, B7-H4 was identified as a coinhibitory member of the B7 family. In mice, B7-H4 expression is limited to B cells and APCs. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. It has also been shown to negatively regulate neutrophil-mediated innate immune responses. Apart from the immune system, B7-H4 is overexpressed on some tumor cancer cells. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells, in the suppression of tumor-associated antigen-specific T-cell immunity.Additional information: Clone REA392 displays negligible binding to Fc receptors. |
| 别名 | Vtcn1, B7h4, B7S1, B7x, BC032925 |
| 克隆号 | REA392 |
| 同种亚型 | recombinant human IgG1 |
