CD125 (IL-5RA)-Biotin, mouse 60 tests
货号：
130-108-400 基本售价：
询价 规格：
60 tests
产品信息
概述| 货号 | 130-108-400 |
| 描述 | Clone REA343 recognizes the mouse CD125 antigen, a single-pass type I membrane protein, also known as interleukin-5 receptor subunit α (IL-5Rα). The IL-5 receptor is a heterodimer composed of a ligand specific α subunit and a signal transducing β subunit which is shared by the receptors for IL-3, GM-CSF, and IL-5. CD125 is expressed on eosinophils, basophils, and B cells. IL-5 is a conserved hematopoietic cytokine which is mainly produced by Tʜ2 cells after stimulation with antigens, and by mast cells upon stimulation with an allergen/IgE complex or a calcium ionophore. The overexpression of IL-5 in vivo significantly increases the numbers of eosinophils and B cells, while mice lacking the functional gene for IL-5 display various developmental and functional impairments in the B cell and eosinophil lineages.Additional information: Clone REA343 displays negligible binding to Fc receptors. |
| 别名 | CDw125, Il5r, IL-5RA |
| 克隆号 | REA343 |
| 同种亚型 | recombinant human IgG1 |
