Ms ICAD Pure Poly1266 200uL
货号：
550736 基本售价：
20424.0 元 规格：
200uL
产品信息
概述| 货号 | 550736 |
| 描述 | Apoptosis is essential in maintaining normal cellular homeostasis and for animal development. Morphological as well as biochemical changes are a hallmark of apoptosis and include membrane blebbing, chromosomal condensation and DNA fragmentation. These changes are caused by a class of cysteine proteases called caspases, which, upon activation can cleave multiple cytoplasmic and nuclear substrates. Caspases, once activated by a proapoptotic signal can induce a DNase, designated DFF/CAD to cleave these nuclear substrates. In growing, non-apoptotic cells DFF/CAD is complexed with its inhibitor, ICAD. Activation of caspase-3 causes the cleavage of ICAD, releasing CAD to cleave chromosomal DNA. ICAD has a molecular weight of approximately ~45 kDa in SDS-PAGE. The antibody recognizes the full length and cleaved form (~18 kDa) of mouse ICAD. A peptide corresponding to amino acids 312 to 331 of mouse ICAD was used as immunogen. |
| 同种亚型 | IgG |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Rabbit |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse ICAD peptide aa. 312-331 |
| 存放说明 | The polyclonal antibody was purified from antiserum by negative adsorption and affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
