Ms TLR7 (CD287) PE A94B10 50ug
货号：
565557 基本售价：
11025.0 元 规格：
50ug
产品信息
概述| 货号 | 565557 |
| 描述 | The A94B10 monoclonal antibody specifically binds to the Toll-like receptor 7 (TLR7) which is also known as CD287. TLR7 is expressed by myeloid and plasmacytoid dendritic cells, and B lymphocytes. TLR7 functions as a pattern recognition receptor that enables the innate immune system to detect single-stranded microbial RNA although it can mistakenly recognize self-derived RNA. TLR7 can be synthesized and transported from the endoplasmic reticulum to endolysosomes upon activation. Full length TLR7 is enzymatically cleaved to form an N-terminal half of the TLR7 ectodomain (TLR7N) that covalently associates with the remaining truncated TLR7 (TLR7C) to form a functional endolysosomal TLR7 (TLR7N-TLR7C) which can sense RNA. TLR7 signals through MYD88 and TRAF6 to activate NF-kappa-B which induces proinflammatory cytokine production. The A94B10 antibody binds to both full length TLR7 and TLR7N, but not to TLR7C alone. Recently, the A94B10 antibody was reportedly found capable of detecting both cleaved and uncleaved forms of cell surface TLR7, and inhibiting in vitro and in vivo cellular responses to various TLR7 ligands. |
| 别名 | TLR7; Tlr7 ; Toll-like receptor 7; CD287 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse TLR7 |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
