Ms CD124 (IL-4R) Pure mIL4R-M2 500ug
货号：
552952 基本售价：
9860.0 元 规格：
500ug
产品信息
概述| 货号 | 552952 |
| 描述 | The mIL4R-M2 monoclonal antibody specifically binds to the α subunit of the mouse Interleukin-4 Receptor (IL-4R α , aka, CD124). The mIL4R-M2 antibody does not recognize human or rat IL-4R; crossreactivities with IL-4R from other species have not been established. The mouse IL-4R α is a 140 kDa transmembrane glycoprotein that is expressed by B and T lymphocytes and a variety of other hematopoietic and nonhematopoietic cells and cell lines. The cell surface IL-4R α chain binds IL-4 with high affinity and associates with either the common γ chain (IL-4R α/γ c; aka, type I IL-4R) or the IL-13 receptor alpha subunit (IL-4R α/IL-13Rα ; aka, type II IL-4R complex) to form two distinct types of signal-transducing IL-4R complexes. The type I IL-4 receptor complex specifically binds IL-4 whereas the type II IL-4R binds and transduces signals from either IL-4 or IL-13. The mIL4R-M2 antibody blocks IL-4 binding to cells and is reported to be a potent inhibitor of IL-4’s biological activities. The mIL4R-M2 antibody also recognizes naturally occurring, soluble truncated forms of IL-4R α (sIL-4R) that result either from enzymatic cleavage of the cell surface extracellular IL-4R α domain or from differential mRNA splicing and secretion by cells. These sIL-4R retain their high-affinity ligand binding domain and appear to either enhance or inhibit IL-4-mediated functions depending on the relative local levels of IL-4 and sIL-4R. The immunogen used to generate the mIL4R-M2 hybridoma was CTLL-19.4 cells, a subclone of CTLL-2 cells that express high levels of IL-4R α. |
| 别名 | IL-4 Receptor α chain |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Rat |
| 使用方法 | ELISA Cap. |
性能| 供应商 | BD Pharmingen |
| 免疫原 | CTLL-19.4 cells |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
