BV711 Hamster Anti-Mouse Vγ 3 TCR
货号：
743242 基本售价：
7000.0 元 规格：
EA
产品信息
概述| 货号 | 743242 |
| 描述 | The 536 monoclonal antibody specifically recognizes V γ 3† T-cell Receptor (TCR)-bearing T lymphocytes, which are the predominant γδ TCR-bearing cells in the early fetal thymus and the adult epidermis of euthymic mice. The first T cells to mature in the embryonic thymus express the V γ 3 and V δ 1 TCR chains, and their development is dependent upon IL-7. There is evidence that the V γ 3 TCR-bearing fetal thymocytes are the precursors of the majority of dendritic epidermal T cells (DEC), which may be replenished in the adult by proliferation in situ rather than by seeding from primary lymphoid organs. Although the V γ 3 TCR is almost exclusively found in the DEC population, it has been shown that the homing of DEC to the epidermis does not require expression of the V γ 3 gene segment. V γ 3 TCR-bearing dermal dendritic cells have also been described. V γ 3 TCR has also been found on a subset of T lymphocytes in the lactating mammary gland and at the site of antigenic challenge in contact-sensitized mice. Plate-bound 536 antibody activates V γ 3 TCR-bearing T cells, and Fab fragments of mAb 536 block in vitro stimulation of DEC by keratinocytes. † Please note that the V γ 3 designation correlates with the nomenclature of Garman, Doherty, and Raulet; the V γ 5 designation of Heilig and Tonegawa is equivalent. |
| 别名 | TCR Vγ3; TCR V gamma 3; TCR Vg3 |
| 同种亚型 | Syrian Hamster IgG1, κ |
| 反应种属 | Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | AKR mouse dendritic epidermal cell clone 7-17 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV711 under optimal conditions that minimize unconjugated dye and antibody.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
