MS CD70 BV650 FR70 50UG
货号：
740532 基本售价：
7000.0 元 规格：
50ug
产品信息
概述| 货号 | 740532 |
| 描述 | The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily. CD70 is the ligand for CD27 and is expressed primarily on activated B cells. CD70 expression can be induced by activation of splenocytes with lipopolysaccharide and stimulatory antibodies specific for IgM, CD40 or both. mRNA coding for CD70 is transiently expressed after Concanavalin A stimulation of splenocytes or thymocytes. CD70 has been observed to be expressed on dendritic cells of Leishmania major -infected mice. The CD27-CD70 interaction delivers costimulatory signals to T cells and NK cells. It has been reported that FR70 antibody blocks binding of mCD27-Ig fusion protein to mouse Cd70 -transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent responses. |
| 别名 | CD27 ligand; CD27l, CD27LG; Tnfsf7; Ki-24 Antigen |
| 同种亚型 | Rat F344, also known as Fischer, CDF IgG2b |
| 反应种属 | Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | BALB/c mouse B lymphoma A20.2J |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV650 under optimal conditions that minimize unconjugated dye and antibody.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
