MS CD212 BV421 114 50UG
货号：
740051 基本售价：
7000.0 元 规格：
50ug
产品信息
概述| 货号 | 740051 |
| 描述 | The 114 monoclonal antibody specifically binds to mouse CD212 (the β 1 subunit of IL-12R β 1), originally termed IL-12R β , of the mouse IL-12 receptor complex. The IL-12R β 1 subunit associates with a β 2 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12R β 1 subunit interacts primarily with IL-12 p40 whereas the IL-12R β 2 binds both to IL-12 p40 and IL-12 p35. IL-12R β 1 is required for high affinity binding of IL-12 but IL-12R β 2 is required for signaling. IL-12R β 1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19. The cytoplasmic regions of the β 1 and β 2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. IL-12R β 1 are primarily expressed by activated T cells and NK cells. Experiments with IL-12R β 1 deficient mice have shown that IL-12R β 1 is necessary for mouse T and NK cell responsiveness to IL-12 p75. The 114 antibody was generated by immunizing IL-12R β 1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12R β1. |
| 别名 | Il12rb1; IL-12R-beta-1; IL-12 Receptor β1 chain |
| 同种亚型 | Mouse IgG2a, κ |
| 反应种属 | Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | IL-12Rβ1 Transfected Cell Line |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV421 under optimal conditions that minimize unconjugated dye and antibody.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
