Ms CD283 (TLR3) PE PaT3 50ug
货号：
565984 基本售价：
6845.0 元 规格：
50ug
产品信息
概述| 货号 | 565984 |
| 描述 | The PaT3 monoclonal antibody specifically binds to the Toll-like receptor 3 (TLR3), which is also known as CD283. CD283 belongs to the mammalian toll-like family of pattern recognition receptors (TLR) which participate in innate immune responses to microbial pathogens. It is a type I transmembrane glycoprotein that has an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the cytoplasmic region of IL-1RI/CD121a. CD283 is differentially expressed on splenic CD8+ dendritic cells, macrophages, and marginal zone B cells. It is expressed on the cell surface as well as intracellular compartments including endolysosomes. As in the case of viral infection, CD283 senses double-stranded RNA (dsRNA) in endolysosomes which subsequently leads to the production of antimicrobial peptides and proinflammatory cytokines by responding cells. CD283 can also be triggered by the synthetic analog, polyinosinic:polycytidylic acid (Poly I:C). The PaT3 monoclonal antibody can reportedly augment TLR3-mediated cellular responses to dsRNA. The PaT3 antibody does not crossreact with human CD283 (TLR3). |
| 别名 | Tlr3; TLR3; Toll-like receptor 3 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse TLR3 Transfected Cell Line |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
