Ms Blimp-1 Alexa 647 5E7 50ug
货号：
563643 基本售价：
6815.0 元 规格：
50ug
产品信息
概述| 货号 | 563643 |
| 描述 | The 5E7 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1). Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene and functions as a transcriptional repressor. Blimp-1 is essential for regulating the terminal differentiation of activated B cells into plasma cells. In this process, Blimp-1 suppresses genes involved in B cell proliferation, such as MycandBcl6. It controls other genes, such as Xbp1, that are required for upregulating the plasma cell’s protein synthesis machinery which is essential for antibody production and secretion. Blimp-1 is an important regulator in other cell types as well. It functions in the regulation of T cell activation and homeostasis and NK cell maturation. Blimp-1 is expressed in activated T cells and can function to inhibit IL-2 production while enhancing the differentiation and expression of several molecules produced by effector T cells. |
| 别名 | Prdm1; PR domain zinc finger protein 1; Blimp1; PRDI-BF1; ZNFPR1A1 |
| 同种亚型 | Rat IgG2a, κ |
| 反应种属 | Mouse (QC Testing) Human (Lack of Reactivity Confirmed in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Blimp-1 Recombinant Protein |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
