Ms IL-23 p19 Alexa 647 N71-1183 50ug
货号：
565317 基本售价：
6750.0 元 规格：
50ug
产品信息
概述| 货号 | 565317 |
| 描述 | The N71-1183 monoclonal antibody specifically recognizes the alpha subunit, also known as p19, of mouse interleukin 23 that is encoded by the Il23a gene. Interleukin 23 (IL-23) is a heterodimeric cytokine composed of a p40 subunit and a p19 subunit. The p19 subunit is unique to IL-23, while the p40 subunit is shared with IL-12 and is also known as IL-12B. Human and mouse p19 share 70% amino acid sequence identity. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4 and TLR8 ligands, as well as the β-glucan receptor, Dectin-1. IL-23 has bio logical activities that are similar to, but distinct from IL-12: Both IL‧12 and IL-23 induce proliferation and IFN-γ production by huma n T cells. While IL-12 acts on both naοve and memory human T cells, the effects of IL-23 are restricted to memory T cells. IL-23, but not IL-12, has been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. In vitro and in vivo treatment with N71-1183 monoclonal antibody has been shown to inhibit IL-23’s ability to enhance IL-17 production by activated MRL/ lpr T lymphocytes (Kyttaris VC, Kampagianni O, Tsokos GC, 2013). |
| 别名 | interleukin-23 subunit alpha; IL-23-A; IL-23p19; Il23a |
| 同种亚型 | Rat IgG1, κ |
| 反应种属 | Mouse (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse IL-23p19 Recombinant Protein |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
